Skip to content. | Skip to navigation

Personal tools

Sections

UMR 5672

logo de l'ENS de Lyon
logo du CNRS
You are here: Home / Seminars / Colloquium / ENSnano: a geometry-based 3D modelling software for designing complex DNA nanostructures

ENSnano: a geometry-based 3D modelling software for designing complex DNA nanostructures

Nicolas Schabanel (Laboratoire de l'Informatique du Parallélisme, Lyon)
When May 15, 2023
from 11:00 to 12:00
Where Amphi Sciences de la Matière
Attendees Nicolas Schabanel
Add event to calendar vCal
iCal

Since the 1990s, increasingly complex nanostructures have been reliably obtained out of self-assembled DNA strands: from ``simple'' 2D shapes to 3D gears and articulated nano-objects, and even computing structures. The success of the assembly of these structures relies on a fine tuning of their structure to match the peculiar geometry of DNA helices. Various softwares have been developed to help the designer.

In this talk, we introduce our new software ENSnano which aim at conciliating the different approaches of preexisting softwares by providing a slick fast-responding interface combining live-editable 2D and 3D views together with new concepts to help the designer. Furthermore we will present new paradigms to design DNA origamis with arbitrary 3D curvatures. These paradigms are now part of ENSnano software and we have used them to create increasingly complex curvy DNA nanostructures with high yield and with high accuracy. These structures were evaluated by atomic force microscopy (AFM), negative stain transmission electronic microscopy (TEM), and cryogenic electron microscopy (3D cryoEM).

More information about this event…