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PhD Project : « Multi-scale modeling of the spatio-temporal programme of replication in the chromatin context »
Institute :
USR3010 Laboratoire Joliot-Curie – ENS de Lyon
PhD supervisor :
Benjamin Audit (CR1 CNRS)
Email adress and phone number :
benjamin.audit(A)ens-lyon.fr - 04 7272 8823
Team members involved :
Alain Arneodo (DR1 CNRS) – Cédric Vaillant (CR1 CNRS)
Project description :
Recent work of the hosting group allowed to progress into the quantitative description of the genome-wide coupling between replication transcription, nuclear organisation, chromatin function and nucleosome positioning. It relies on an original segmentation of the human genome into replication domains obtained using a multi-scale analysis of DNA compositional asymmetry profiles. Taking advantage of recent advances into genome-wide characterisation of replication timing for a number of cell lines (RepliSeq data), we propose a PhD research project aiming at building a spatio-temporal model of the replication programme. In a first step, coupling the replication domain segmentation with multi-scale analyses of replication timing profiles will allow to characterise the different mode of replication observe along the human genome. The second step will consist in delineating the main determinants (chromatin state, transcriptional activity), associate and possibly responsible for each mode of replication. This information will eventually be combined into a multi-scale model integrating local (kbp scale) determinants such as the structure of the nucleosomal array into the large-scale (Mbp scale) programme of replication.
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