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Équipes

Épissage alternatif et progression tumorale - D. Auboeuf

Plus de 90% des gènes humains génèrent plusieurs transcrits codant pour des isoformes protéiques différentes grâce à l’épissage alternatif, un mécanisme permettant d’augmenter d’un facteur 10 la diversité du protéome codé par un nombre limité de gènes.

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Architecture et Dynamique Fonctionnelle des Chromosomes - P. Bernard

The main goal of our research is to understand the mechanisms used by cells to assemble mitotic chromosomes that can be efficiently transmitted throughout cell divisions. We use the fission yeast Schizosaccharomyces pombe as a model organism.

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Plasticité et Evolution de la Division Cellulaire - M. Delattre

The cell is a level of biological organisation that has been poorly explored from an evolutionary perspective. How do cellular mechanisms evolve? What is the extent of possible solutions that have been retained across evolution to achieve basic cellular functions?

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Quantitative regulatory genomics - M. Francesconi

Why are individuals different? We address this fundamental question by studying both genetic and non-genetic sources of phenotypic variation, using both genome-wide computational and experimental systems biology approaches in model organisms. In particular, we are interested in understanding how gene expression is regulated in space and time to contribute to phenotypic variation.

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Systems Biology of Decision Making - O. Gandrillon

The molecular mechanisms controlling decision making at the cellular level between self-renewal and differentiation are still poorly understood. The central question of our group consists in understanding the molecular mechanisms controlling self-renewal and the alteration of these mechanisms in relation to the onset of cancer.

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Epithelial differentiation and morphogenesis in Drosophila - M. Grammont

Epithelia form a vital part of all our tissues and organs. The adhesive properties of these cellular sheets and the ability of their component cells to change shape and/or to move are essential to generate a large number of tissues and organs.

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Contrôle de l’Expression Génétique et Oncogenèse Virale - Jalinot/Duc Dodon

Our main research interest is to decipher the molecular mechanisms underlying oncogenesis, with a particular interest in the role of genetic instability in the process. Towards this goal we focused our attention on leukemogenesis driven by infection with the human T-cell lymphotropic virus type 1 (HTLV-1).

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Apoptosis and Neurogenetics - B. Mollereau

The general goal of our lab is to understand the mechanisms of cell death, ER stress, autophagy and metabolism during development and in neurodegenerative diseases. We characterize those responses in physiological and pathological situations in the Drosophila retina, brain and during spermatogenesis.

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Régulation Epigénétique au cours du Développement - F. Palladino

We are interested in understanding the role of conserved chromatin marks in the maintenance of germline identity and the response to environmental stress. To adress these questions, we are using C. elegans as a model organism. We use a combination of genetic, biochemical and genome wide approaches.

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Comparative and Integrative Genomics of Organ Development - S.Pantalacci/M. Semon

We compare genomes and transcriptomes to highlight general rules about the development and/or the evolution of organs.

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Métabolisme des ARNs au cours de la réponse immunitaire et de l’infection - E. Ricci

We are interested in post-transcriptional control mechanisms that regulate gene expression in cells of the immune system and during pathogen infections. Through the use of high-throughput sequencing and biochemical approaches we aim at identifying new regulatory layers that govern immune cell activation and host-pathogen interactions.

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Structures et Interactions des Molécules Biologiques - M. Spichty

We apply atomic-level computer simulations and molecular and cellular biology experiments to gain insights into the dynamic structure of proteins and their interactions in living cells. The main goal is to understand the factors that determine the interaction strength between proteins and how the cell modulates these interactions to regulate biological functions.

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Génétique des Variations Intra-Espèce - G. Yvert

Notre équipe étudie les mécanismes génétiques fondamentaux responsables des différences observables entre individus de la même espèce. L'enjeu est de mieux comprendre pourquoi certains individus sont plus disposés que d'autres à développer certains phénotypes.

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