Skip to content. | Skip to navigation

Personal tools

Sections
You are here: Home / Teams

Teams

Alternative splicing and tumoral progression - D. Auboeuf

Our team is interested in the regulation of alternative splicing, the main process allowing to largely increase the functional diversity of proteins coded by a limited number of genes in higher organisms.

Read More…

Chromatin Dynamics in Chromosome Architecture - P. Bernard

The ability of the genome to adopt a dynamic 3D organisation underlies most DNA transactions. The profound reorganisation of long chromatin fibres into rod-shaped chromosomes in mitosis is an iconic example of this structural dynamics. The main goal of our research is to understand the cellular mechanisms that take place at the chromatin level for the assembly of segregation-competent mitotic chromosomes. We use the fission yeast Schizosaccharomyces pombe and human cultured cells as model systems.

Read More…

http://www.ens-lyon.fr/LBMC/equipes/leadImage_thumb

Plasticity and Evolution of the Cell Division - M. Delattre

The cell is a level of biological organisation that has been poorly explored from an evolutionary perspective. How do cellular mechanisms evolve? What is the extent of possible solutions that have been retained across evolution to achieve basic cellular functions?

Read More…

Quantitative regulatory genomics - M. Francesconi

Why are individuals different? We address this fundamental question by studying both genetic and non-genetic sources of phenotypic variation, using both genome-wide computational and experimental systems biology approaches in model organisms. In particular, we are interested in understanding how gene expression is regulated in space and time to contribute to phenotypic variation.

Read More…

Systems Biology of Decision Making - O. Gandrillon

The molecular mechanisms controlling decision making at the cellular level between self-renewal and differentiation are still poorly understood. The central question of our group consists in understanding the molecular mechanisms controlling self-renewal and the alteration of these mechanisms in relation to the onset of cancer.

Read More…

Epithelial differentiation and morphogenesis in Drosophila - M. Grammont

Epithelia form a vital part of all our tissues and organs. The adhesive properties of these cellular sheets and the ability of their component cells to change shape and/or to move are essential to generate a large number of tissues and organs.

Read More…

Posttranscriptional Regulation in Infection and Oncogenesis - Jalinot/Mocquet

Our main research interest is to decipher the molecular mechanisms underlying oncogenesis, with a particular interest in the role of genetic instability in the process. Towards this goal we focused our attention on leukemogenesis driven by infection with the human T-cell lymphotropic virus type 1 (HTLV-1).

Read More…

Apoptosis and Neurogenetics - B. Mollereau

The general goal of our lab is to understand the mechanisms of cell death, ER stress, autophagy and metabolism during development and in neurodegenerative diseases. We characterize those responses in physiological and pathological situations in the Drosophila retina, brain and during spermatogenesis.

Read More…

Epigenetic regulation of cell identity and environmental stress responses - F. Palladino

We are interested in understanding the role of conserved chromatin marks in the maintenance of germline identity and the response to environmental stress. To adress these questions, we are using C. elegans as a model organism. We use a combination of genetic, biochemical and genome wide approaches.

Read More…

Comparative and Integrative Genomics of Organ Development - S.Pantalacci/M. Semon

We compare genomes and transcriptomes to highlight general rules about the development and/or the evolution of organs.

Read More…

RNA metabolism in immunity and infection (RMI2) - E. Ricci

We are interested in post-transcriptional control mechanisms that regulate gene expression in cells of the immune system and during pathogen infections. Through the use of high-throughput sequencing and biochemical approaches we aim at identifying new regulatory layers that govern immune cell activation and host-pathogen interactions.

Read More…

http://www.ens-lyon.fr/LBMC/equipes/leadImage_thumb

Genetic Complexity of Living Systems - G. Yvert

Our research group is interested in the fundamental genetic mechanisms underlying inter-individual phenotypic differences. We wish to better understand why some individuals are more likely than others to develop specific traits.

Read More…

Epigenetics and Zygote Formation - B. Loppin

The formation of a diploid zygote from two highly different gametes is a critical aspect of sexual reproduction in animals. Notably, the transmission of the paternal genome implies unique chromatin reorganization events that take place during spermiogenesis and at fertilization.

Read More…

Physical Biology of Chromatin - D. Jost

In close connection with experimental biology, our research addresses generic or specific biological questions on chromatin and gene regulation by developing physical and computational models. Particularly, we focus on the spatio-temporal dynamics of eukaryotic chromosomes. Our research tackles important questions regarding the coupling between 3D structure and functions of chromatin. Our objective is to provide some universal principles driving chromatin folding and regulation, while contextualizing our approaches to fundamental, specific problems of 3D genomics.

Read More…

Genome mechanics - A. Piazza

Homologous recombination is a universal DNA break repair pathway involved in a variety of biological processes. Our goal is to define the molecular mechanisms of this complex pathway and their interplay with the spatial organization of the genome.

Read More…