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Bertrand Mollereau’s lab has a long interest and extensive expertise on neuron development and cell death in Drosophila. In 2006, B. Mollereau started his group at the ENS of Lyon where he developed a novel model of neurodegeneration using the Drosophila visual system. Taking advantage of a poweful genetic screens in Drosophila, his group showed that mild ER stress promotes neuroprotection in the retina as well as in Drosophila and mouse models of Parkinson's disease. In recent work, his group showed 1) a survival role of fatp in the generation of lipid droplet in the glial/pigment cells of the Drosophila visual system; 2) the inhibitory function of caspases on autophagy flux and 3) a novel mechanism of programmed necrosis to regulate germ cell number during spermatogenesis. Pr. Mollereau’s group at the ENSL has currently 7 members including 1 Pr and 2 lecturers (MDC), 3 PhD students and 1 senior research assistant (IE, CNRS).

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