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Vous êtes ici : Accueil / Équipes / Mort Cellulaire Régulée et Génétique de la Neurodégénerescence - B. Mollereau / Publications / Translationally controlled tumor protein is a conserved mitotic growth integrator in animals and plants.

Translationally controlled tumor protein is a conserved mitotic growth integrator in animals and plants.

Florian Brioudes, Anne-Marie Thierry, Pierre Chambrier, Bertrand Mollereau, and Mohammed Bendahmane (2010)

Proc Natl Acad Sci U S A, 107(37):16384-9.

The growth of an organism and its size determination require the tight regulation of cell proliferation and cell growth. However, the mechanisms and regulatory networks that control and integrate these processes remain poorly understood. Here, we address the biological role of Arabidopsis translationally controlled tumor protein (AtTCTP) and test its shared functions in animals and plants. The data support a role of plant AtTCTP as a positive regulator of mitotic growth byspecifically controlling the duration of the cell cycle. We show that, in contrast to animal TCTP, plant AtTCTP is not implicated in regulating postmitotic growth. Consistent with this finding, plant AtTCTP can fully rescue cell proliferation defects in Drosophila loss of function for dTCTP. Furthermore, Drosophila dTCTP is able to fully rescue cell proliferation defects in Arabidopsis tctp knockouts. Our data provide evidence that TCTP function in regulating cell division is part of a conserved growth regulatory pathway sharedbetween plants and animals. The study also suggests that, although the cell division machinery is shared in all multicellular organisms to control growth, cell expansion can be uncoupled from cell division in plants but not in animals.

 
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