Skip to content. | Skip to navigation

Personal tools

Sections
You are here: Home / Teams / Apoptosis and Neurogenetics - B. Mollereau / Publications / Disturbance of endoplasmic reticulum proteostasis in neurodegenerative diseases.

Disturbance of endoplasmic reticulum proteostasis in neurodegenerative diseases.

Claudio Hetz and Bertrand Mollereau (2014)

Nat Rev Neurosci, 15(4):233-49.

The unfolded protein response (UPR) is a homeostatic mechanism by which cells regulate levels of misfolded proteins in the endoplasmic reticulum (ER). Although it is well characterized in non-neuronal cells, a proliferation of papers over the past few years has revealed a key role for the UPR in normal neuronal function and as an important driver of neurodegenerative diseases. A complex scenario is emerging in which distinct UPR signalling modules have specific and even opposite effects on neurodegeneration depending on the disease context. Here, we provide an overview of the most recent findings addressing the biological relevance of ER stress in the nervous system.

 
automatic medline import

Document Actions