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Vous êtes ici : Accueil / Équipes / Evolution des Processus Cellulaires chez les Nématodes - M. Delattre / Publications / The first steps in the life of a worm: Themes and variations in asymmetric division in C. elegans and other nematodes.

The first steps in the life of a worm: Themes and variations in asymmetric division in C. elegans and other nematodes.

Marie Delattre and Nathan W Goehring (2021)

Curr Top Dev Biol, 144:269-308.

Starting with Boveri in the 1870s, microscopic investigation of early embryogenesisin a broad swath of nematode species revealed the central role of asymmetric celldivision in embryonic axis specification, blastomere positioning, and cell fatespecification. Notably, across the class Chromadorea, a conserved themeemerges-asymmetry is first established in the zygote and specifies its asymmetricdivision, giving rise to an anterior somatic daughter cell and a posterior germlinedaughter cell. Beginning in the 1980s, the emergence of Caenorhabditis elegans as amodel organism saw the advent of genetic tools that enabled rapid progress in ourunderstanding of the molecular mechanisms underlying asymmetric division, in manycases defining key paradigms that turn out to regulate asymmetric division in a widerange of systems. Yet, the consequence of this focus on C. elegans came at theexpense of exploring the extant diversity of developmental variation exhibitedacross nematode species. Given the resurgent interest in evolutionary studiesfacilitated in part by new tools, here we revisit the diversity in this asymmetricfirst division, juxtaposing molecular insight into mechanisms of symmetry-breaking,spindle positioning and fate specification, with a consideration of plasticity andvariability within and between species. In the process, we hope to highlightquestions of evolutionary forces and molecular variation that may have shaped theextant diversity of developmental mechanisms observed across Nematoda.

 
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