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Vous êtes ici : Accueil / Équipes / Régulation Post-transcriptionnelle dans l'Infection et l'Oncogenèse - Jalinot/Mocquet / Publications / Voltage-gating of aquaporins, a putative conserved safety mechanism during ionic stresses.

Voltage-gating of aquaporins, a putative conserved safety mechanism during ionic stresses.

Robin Mom, Beatriz Muries, Pierrick Benoit, Julien Robert-Paganin, Stéphane Réty, Jean-Stéphane Venisse, Agilio Padua, Philippe Label, and Daniel Auguin (2021)

FEBS Lett, 595(1):41-57.

Aquaporins are transmembrane water channels found in almost every livingorganism. Numerous studies have brought a good understanding of both watertransport through their pores and the regulations taking place at the molecularlevel, but subtleties remain to be clarified. Recently, a voltage-related gatingmechanism involving the conserved arginine of the channel's main constriction wascaptured for human aquaporins through molecular dynamics studies. With a similarapproach, we show that this voltage-gating could be conserved among this familyand that the underlying mechanism could explain part of plant AQPs diversity whencontextualized to high ionic concentrations provoked by drought. Finally, weidentified residues as adaptive traits which constitute good targets for droughtresistance plant breeding research.

 
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