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Characterize the NMD pathway and its deregulation by viral factors (Vincent Mocquet- projet 1)

The NMD is a quality control pathway leading to the degradation of RNA that harbor ribosomes considered by the cell to have prematurely stopped.

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Effects of DHX36 on RNA G4 quadruplexes (Stéphane Réty- projet 2)

G-quadruplexes (G4s) are four-stranded secondary structures held together by layers of four Guanines (G) interacting by non-canonical G-G base pairs. Once formed, G4s are highly stable and can act as barriers blocking replication, transcription and translation.

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Control of histone expression by INT6 and SLBP (Pierre Jalinot- projet 3)

Strenghthening the role of INT6 in genome stability, we have shown that INT6 is needed for efficient expression of the histones during the S phase of the cell cycle.

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Exploring how INT6/EIF3E influences DNA repair - Implications in cancer therapy (Christelle Morris- projet 4)

We identify the antioncogenic breast cancer factor INT6/EIF3E as an essential regulator of DNA damage signaling and repair in human cells

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