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UMR 5672

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Microscopy image analysis

(PEPS PROMIS, L. Condat, GIPSA-lab, J. Boulanger, Institut Curie) Structured illumination microscopy increases fluorescence microscopy resolution without constraint on protein marking. This modality is based on the acqui- sition on several low resolution modulated images fol- lowed by a post-processing that aims at reconstruct- ing the high resolution image. The first contribution concerns the estimation of the modulation parameters from the low resolution modulated images while the second contribution aims at providing an efficient reconstruction procedure based on non-smooth convex optimization. Such a framework allows us to deal with a variational approach where the data fidelity term and the regularization term are fitted to the degradation model (Poisson noise) and to the data (filaments that models actin and microtubules, spots such as single molecules or vesicles).