Directory
Pr. Joseph MORAN
| When |
Jun 04, 2015 à 01:30 PM |
|---|---|
| Where |
CBP LR6 main lecture room |
| Contact |
Jens Haserodt |
Harnessing Complexity in Catalysis: From Self-Assembling H-Bond Catalysts to Discovery Strategies
The spatial pre-organization of multiple hydrogen bond donor sites within the molecular framework of enzymes is a major reason why biological catalysts produce dramatic rate acceleration with impressive selectivity. Supramolecular pre-organization of multiple hydrogen bond catalysts can also lead to much higher reaction rates while providing a modular and easily tunable catalyst system without the need for intensive synthetic efforts. The first half of the talk will describe our efforts to develop and exploit self-assembling hydrogen bond catalysts.[1]
Catalyst discovery is a multidimensional problem that often requires extensive experimentation to obtain a lead result. The second half of the talk will describe our efforts to generate, screen and deconvolute complex mixtures of catalysts, a technique that can dramatically reduce the number of reactions required to obtain a lead result.[2]