Biomimetic Polymer Vesicles:

Virus and Cell Mimics towards innovative biomaterials

LECOMMANDOUX Sébastien^{1, a *}

¹ Laboratoire de Chimie des Polymères Organiques, Univ. Bordeaux, CNRS UMR 5629, Bordeaux-INP ENSCBP, Pessac, France

^a Lecommandoux@enscbp.fr

Keywords: polymersome, self-assembly, drug-delivery, artificial cell, polypeptide, polysaccharide.

Abstract. Polymersomes (polymer vesicles) are among the most attractive systems for drug delivery applications. We report here an overview on the self-assembly in water of amphiphilic block copolymers into polymersomes, and their applications in loading and controlled release of both hydrophilic and hydrophobic molecules and biomolecules.

We pay special attention to polysaccharide and polypeptide-based block copolymer vesicles and their development in nanomedicine.^[1-5] These copolymers that mimic the structure and some function of glycoproteins on virus represent an example of the effectiveness of a biomimetic strategy in implementing materials design. We especially evidenced the particular benefit of nanoparticles and their multivalency toward the interaction with biological receptors.^[6-8] Finally, our recent advances in using “biomimicry approaches” to design complex, compartmentalized and functional protocells will be proposed. Such a system constitutes a first step towards the challenge of structural cell mimicry and functionality.^[9-12]

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