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Bertrand Mollereau — Modeling Neurodegenerative diseases in Drosophila

Speaker :

Bertrand Mollereau, Apoptosis and Neurogenetics, LBMC, ENS-Lyon

When :

Wednesday 1 June at 11am

Where :

C023 (RDC LR6 côté Centre Blaise Pascal)

Title :

Modeling Neurodegenerative diseases in Drosophila

Abstract :

The Drosophila eye is an excellent model to study neurodegenerative diseases such as Parkinson or retinal diseases. The ectopic expression of pathological proteins in the retina leads to progressive degeneration of photoreceptor cells with similar features as in human diseases.

The goal of our studies is to increase the understanding of the molecular mechanisms of neurodegeneration. As neuronal differentiation reaches its completion, the mechanisms regulating cell death become strongly repressed. This allows the neural tissue to be maintained in the organism.

We have recently developed a new two-color in vivo imaging system, termed the “Tomato/GFP-FLP/FRT” method by combining mitotic recombination and cornea neutralization techniques. Using this method, we can directly visualize mutant photoreceptor at a single-cell resolution while simultaneously identifying mutations affecting photoreceptor survival and apoptosis in the adult fly.

I will focus my presentation on selected mutations that highlight new mechanisms regulating photoreceptor survival and death.

For information about our other projects visit our website.

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