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François Parcy — Can genomic sequences help us to understand flower evolution ?
Speaker :
François Parcy, Laboratoire Physiologie Cellulaire Végétale, CNRS, CEA, INRA, UJF, Grenoble
When :
Wednesday 5 october at 11am
Where :
C023 (RDC LR6 côté Centre Blaise Pascal)
Title :
Can genomic sequences help us to understand flower evolution ?
Abstract :
LEAFY is a unique plant transcription factor, which plays a conserved role in angiosperm flower development. The resolution of the crystallographic structure of its DNA binding domain revealed that it is a novel type of Helix-Turn-Helix transcription factor contacting DNA over a large region. To predict the sequence bound by LEAFY, we built a biophysical model describing LFY DNA binding specificity in vitro and verified that it accurately predicts in vivo LFY binding sites in the Arabidopsis thaliana genome. Using high throughput Selex, we have shown that LFY DNA binding specificity is highly conserved in Angiosperms. We thus extended model built in Arabidopsis to other species and we showed that some regulatory relationships between LFY and its floral targets could be detected directly from Angiosperms genomic sequences. To understand the evolutionary origin of the gene regulatory network linking LFY and floral homeotic genes present in Angiosperms, we also studied the Gymnosperm Welwitschia mirabilis. Combining in vivo expression data with biochemical analysis, we obtained evidence in favor of the existence of a pre-floral network in this plant.
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