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Located in Teams / Evolutionary Cell Biology in Nematodes - M. Delattre
Physical Biology of Chromatin - D. Jost
In close connection with experimental biology, our research addresses generic or specific biological questions on chromatin and gene regulation by developing physical and computational models. Particularly, we focus on the spatio-temporal dynamics of eukaryotic chromosomes. Our research tackles important questions regarding the coupling between 3D structure and functions of chromatin. Our objective is to provide some universal principles driving chromatin folding and regulation, while contextualizing our approaches to fundamental, specific problems of 3D genomics.
Located in Teams
Epigenetic regulation of cell identity and environmental stress responses - F. Palladino
We are interested in understanding the role of conserved chromatin marks in the maintenance of germline identity and the response to environmental stress. To adress these questions, we are using C. elegans as a model organism. We use a combination of genetic, biochemical and genome wide approaches.
Located in Teams
Presentation
Epigenetic regulation during development
Located in Teams
Presentation
ReGArDS - Regulation of Genome Architecture and Dynamics of Splicing
Located in Teams / Regulation of Genome Architecture and Dynamics of Splicing (ReGArDS) - D. Auboeuf and C. Bourgeois
Regulation of Genome Architecture and Dynamics of Splicing (ReGArDS) - D. Auboeuf and C. Bourgeois
Our team is interested in the regulation of alternative splicing, the main process allowing to largely increase the functional diversity of proteins coded by a limited number of genes in higher organisms.
Located in Teams
Condensin in the context of chromatin - P. Bernard
Determining (1) the mechanisms that make chromatin suitable for condensin action in vivo,(2) the role of condensin at telomeres, and (3) the link between condensin and S phase.
Located in Teams / Chromatin Dynamics in Mitotic Chromosome Assembly - P. Bernard
Chromatin Dynamics in Mitotic Chromosome Assembly - P. Bernard
The ability of the genome to adopt a dynamic 3D organisation underlies most DNA transactions. The profound reorganisation of long chromatin fibres into rod-shaped chromosomes in mitosis is an iconic example of this structural dynamics. The main goal of our research is to understand the cellular mechanisms that take place at the chromatin level for the assembly of segregation-competent mitotic chromosomes. We use the fission yeast Schizosaccharomyces pombe and human cultured cells as model systems.
Located in Teams