Annuaire
Bastien BOUSSAU Laboratoire de Biométrie et Biologie Évolutive, Lyon
| Quand ? |
Le 17/05/2024, de 11:00 à 12:00 |
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| S'adresser à | Salle des Thèses, Equipe Pellarin Martin |
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Identifying the footprints of selection in coding sequences can inform about the importance and function of individual sites. Analyses of the ratio of nonsynonymous to synonymous substitutions have been widely used to pinpoint changes in the intensity of selection, but cannot distinguish them from changes in the direction of selection, that is, changes in the fitness of specific amino acids at a given position. A few methods that rely on amino-acid profiles to detect changes in directional selection have been designed, but their performances have not been well characterized. In this presentation, I present a new method named Pelican and show on simulated data that it performs better than competing approaches. In particular, it can be used to look for sites that are associated to discrete phenotypes. Then I present the results of an analysis of 116 mammalian genomes to look for sites associated to several phenotypes of interest (e.g., diet, echolocation, aquatic lifestyle, etc.). Finally, I explain how our approach can be extended to look for correlations with continuous phenotypes such as size or longevity.
Contact : Guillaume Launay