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Francois MAJOR, Institute for Research in Immunology and Cancer, University of Montreal
| When |
May 23, 2025
from 11:00 to 12:00 |
|---|---|
| Contact Name | Equipe Jouravleva, Salle des Thèses |
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MicroRNAs (miRNAs) are key regulators of gene expression, acting through complex interactions with target transcripts. In this talk, I present a predictive framework for modeling miRNA-mediated regulation, spanning from the structural features of individual miRNA-target duplexes to the construction of transcriptome-wide regulatory maps. By integrating RNA structure, target accessibility, and binding affinity, alongside network resolution methods inspired by stable matching theory, this approach captures the combinatorial logic of miRNA targeting. Case studies, including miR-34a’s regulation of SIRT1, illustrate how structural modeling informs regulatory outcomes. The platform also supports the simulation of regulatory rewiring through synthetic or therapeutic RNAs, offering insights into gene control mechanisms and opportunities for targeted intervention in complex diseases.
Contact : Karina Jouravleva