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Hyun (Joy) Kim - School of Biological Sciences, Seoul National University, Seoul, South Korea
| When |
Jul 07, 2025
from 11:00 to 12:00 |
|---|---|
| Contact Name | Equipe Pellarin Martin, Salle des Thèses |
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Secretory proteins are critically dependent on the correct processing of their signal sequence by the signal peptidase complex (SPC). This step, which is essential for the proper folding and localization of proteins in eukaryotic cells, is still not fully understood. By combining cleavage profiling of a set of natural and designed signal sequences with molecular dynamics simulations, our data show how Spc1 and Spc2, two non-catalytic subunits modulate the functional properties of the yeast SPC and its immediate membrane environment, enhancing its ability to discriminate between different types of signal sequences. These results provide new insights into the molecular mechanisms by which SPC governs protein biogenesis.
Contact: Paulo Telles de Souza