Yubin GONG - University of Electronic Science and Technology of China (UESTC)

The vibrational and rotational frequencies of biomolecules reside within the terahertz (THz) band, enabling potential interactions between THz electromagnetic signals and biological molecules under specific conditions. This presentation explores the transformative potential of THz technology in modulating voltage-gated calcium channels (Cav1.2 and Cav2.1) and AMPA receptor-glutamate interactions, providing a novel regulatory tool for neuroscience and biophysics. By exploiting the resonance between THz waves and vibrational modes of biomolecules, we achieve precise, non-invasive control over ion channel gating kinetics and neurotransmitter-receptor binding dynamics. Molecular dynamics simulations and electrophysiological recordings reveal frequency-specific THz modulation of Cav1.2/Cav2.1 activation thresholds and selective suppression of AMPA-Glu binding, laying the foundation for developing innovative non-invasive therapeutic technologies. These findings not only deepen our understanding of THz-bio interactions but also pioneer a new paradigm for non-invasive neuromodulation, with profound implications for treating channelopathies and neurological disorders. By integrating THz science, biophysics, and neuroscience, this work advances fundamental research on the interplay between physical stimuli and biological systems, establishing a cornerstone for precision medicine.

Chair Prof. Yubin GONG

University of Electronic Science and Technology of China (UESTC)

Prof. Yubin Gong is currently a full and chair professor at the University of Electronic Science and Technology of China (UESTC), where he became a faculty member in 1991. He received his Bachelor's degree in Applied Optics from Changchun University of Science and Technology in 1989, Master's degree and Ph.D. in Physical Electronics from UESTC in 1992 and 1998 respectively. He was a visiting scholar at the City University of Hong Kong from 1998 to 1999. With a long-term dedication to scientific research and teaching in the fundamental theories, key technologies and applications of physical electronics, Prof. Gong’s research mainly focus on novel radiation mechanisms and principles of terahertz vacuum electron devices, as well as application of vacuum electron devices in life science. He has published over 300 academic papers in important journals and conferences, delivered keynote talks at numerous academic conferences, and hold more than thirty patents. Over the past decade, he has trained more than forty master and doctoral students.

Contact: Paulo Telles de Souza