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You are here: Home / Teams / RNA metabolism in immunity and infection (RMI2) - E. Ricci / Publications / A long noncoding RNA mediates both activation and repression of immune response genes.

A long noncoding RNA mediates both activation and repression of immune response genes.

Susan Carpenter, Daniel Aiello, Maninjay K Atianand, Emiliano P Ricci, Pallavi Gandhi, Lisa L Hall, Meg Byron, Brian Monks, Meabh Henry-Bezy, Jeanne B Lawrence, Luke AJ O'Neill, Melissa J Moore, Daniel R Caffrey, and Katherine A Fitzgerald (2013)

Science, 341(6147):789-92.

An inducible program of inflammatory gene expression is central to antimicrobialdefenses. This response is controlled by a collaboration involving signal-dependent activation of transcription factors, transcriptional co-regulators, and chromatin-modifying factors. We have identified a long noncoding RNA (lncRNA) that acts as a key regulator of this inflammatory response. Pattern recognition receptors such as the Toll-like receptors induce the expression of numerous lncRNAs. One of these, lincRNA-Cox2, mediates both the activation and repression of distinct classes of immune genes. Transcriptional repression of target genes is dependent on interactions of lincRNA-Cox2 with heterogeneous nuclear ribonucleoprotein A/B and A2/B1. Collectively, these studies unveil a central role of lincRNA-Cox2 as a broad-acting regulatory component of the circuit that controls the inflammatory response.

 
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