UMR 5182

logo-ensl
You are here: Home / Research / Axes / Supramolecular Chemistry and Chemical Biology / Chemical Biology and Biosensing

Chemical Biology and Biosensing

Our group performs research into the design and synthesis of small molecules for application at the nexus with biology.


Fluorogenic probes REsponding to enzyme activity

J.HaSSERODT

A major goal of J. Hasserodt’s research activities is the maturation of a line of imaging probes that depict enzyme activity with spatial resolution in biological samples, live cells and multi-cellular organisms. 

 

 

More

 

Magnetogenic probes responding to enzyme activity

J. Hasserodt

 A second pillar of J. Hasserodt’s research consists in the development of a new line of molecular probes responding to specific enzyme activity (and other chemical analytes) by changing the electronic spin state of the probe.

 More

 

Xenon-cryptophane probes for MRI

 T. BRotin

The xenon-cryptophane complexes using hyperpolarized xenon have shown their high potential as contrast agents for MRI. Our group will pursue the design of xenon-cryptophane complexes for the detection of low concentrations of analytes or the association with proteins for in-vivo and in-vitro experiments. 

More

 

Inhibitors

 P. Maurin

Design and synthesis of potential inhibitors of HIV-1 integrase : this project in collaboration with theoretical chemists, biologists and cristallographers aims to develop (conception synthesis, and biological evaluation) a new class of inhibitors of the HIV-1 integrase with a different and complementary (oligomerisation inhibitors) mode of action than the only inhibitor available (Raltegravir) approved by FDA that is active against the strand transfer step.