UMR 5182

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Chemical Biology and Biosensing

Our group performs research into the design and synthesis of small molecules for application at the nexus with biology.

Fluorogenic probes REsponding to enzyme activity


A major goal of J. Hasserodt’s research activities is the maturation of a line of imaging probes that depict enzyme activity with spatial resolution in biological samples, live cells and multi-cellular organisms. 





Magnetogenic probes responding to enzyme activity

J. Hasserodt

 A second pillar of J. Hasserodt’s research consists in the development of a new line of molecular probes responding to specific enzyme activity (and other chemical analytes) by changing the electronic spin state of the probe.



Xenon-cryptophane probes for MRI

 T. BRotin

The xenon-cryptophane complexes using hyperpolarized xenon have shown their high potential as contrast agents for MRI. Our group will pursue the design of xenon-cryptophane complexes for the detection of low concentrations of analytes or the association with proteins for in-vivo and in-vitro experiments. 




 P. Maurin

Design and synthesis of potential inhibitors of HIV-1 integrase : this project in collaboration with theoretical chemists, biologists and cristallographers aims to develop (conception synthesis, and biological evaluation) a new class of inhibitors of the HIV-1 integrase with a different and complementary (oligomerisation inhibitors) mode of action than the only inhibitor available (Raltegravir) approved by FDA that is active against the strand transfer step.