Directory
Inhibitors
Design and synthesis of potential inhibitors of HIV-1 integrase
This project in collaboration with theoretical chemists, biologists and cristallographers aims to develop (conception synthesis, and biological evaluation) a new class of inhibitors of the HIV-1 integrase with a different and complementary (oligomerisation inhibitors) mode of action than the only inhibitor available (Raltegravir) approved by FDA that is active against the strand transfer step.