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Daniel Needleman — Physical Aspects of Spindle Assembly

Speaker :

Daniel Needleman, Harvard School of Engineering and Applied Sciences, Cambridge, USA

When :

Wednesday 12 october at 2pm

Where :

room 117

Title :

Physical Aspects of Spindle Assembly

Abstract :

Spindles are arrays of microtubules that segregate chromosomes during cell division. It has been difficult to validate models of spindle assembly due to a lack of information on the organization and dynamics of microtubules in these structures. I will present our efforts to combine novel quantitative experiments and theory to understand spindle self-organization. Our results rule out previously proposed models of spindle assembly and suggest a novel mechanism by which the behaviors of microtubules give rise to the spindle.

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