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Chromatin Dynamics in Mitotic Chromosome Assembly - P. Bernard
The ability of the genome to adopt a dynamic 3D organisation underlies most DNA transactions. The profound reorganisation of long chromatin fibres into rod-shaped chromosomes in mitosis is an iconic example of this structural dynamics. The main goal of our research is to understand the cellular mechanisms that take place at the chromatin level for the assembly of segregation-competent mitotic chromosomes. We use the fission yeast Schizosaccharomyces pombe and human cultured cells as model systems.
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ReGArDS - Regulation of Genome Architecture and Dynamics of Splicing
Located in Teams / Regulation of Genome Architecture and Dynamics of Splicing (ReGArDS) - D. Auboeuf and C. Bourgeois
Bibliography Folder Molecular and Cellular Biology
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Bibliography Folder Publications
Located in Teams / Genome mechanics - A. Piazza
Dynamics and Control of Biological Assemblies and Macromolecular Machines - J. Martin / R. Pellarin
We are a horizontal team of four researchers in computational biology. We study molecular machines and assemblies at different scales (atomistic, coarse-grained, normal modes analysis, and kinetic models) in order to understand and control their functioning in cellular and pathological context. Leveraging the power of molecular modeling, we employ advanced techniques and high performance computing to simulate and analyze the behavior of biological molecules with a focus on unraveling the intricacies of their interactions. Our expertise extends to structural bioinformatics, computational chemistry and integrative modeling where we combine in silico approaches and experimental data to extract meaningful information from biological data, aiding in the interpretation and control of complex molecular structures, their interactions and functions.
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