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Stephan HAMPERL - Helmholtz university, Munich
Transcription-replication conflicts cause R-loop-dependent chromatin alterations
| When |
Jun 20, 2025
from 11:00 to 12:00 |
|---|---|
| Contact Name | Salle des Thèses, Equipe Bernard |
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R-loops are three-stranded nucleic acid structures that form co-transcriptionally and which are comprised of an RNA-DNA hybrid and a displaced strand of ssDNA. Although R-loops have important functions in cells, their dysregulation can also lead to genome stability. We recently showed that R-loops forming at engineered transcription-replication conflict sites lead to reduced nucleosome occupancy and replication fork blockage. In this seminar, I will describe our recent studies how these R-loop/TRC-dependent chromatin alterations can also impact the functional state of cells and threaten cellular identity.
https://www.helmholtz-munich.de/en/ies/research-groups/hamperl-lab
Contact : V. Vanoosthuyse