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You are here: Home / Teams / Posttranscriptional Regulation in Infection and Oncogenesis - Jalinot/Mocquet / Publications / The Complex Relationship between HTLV-1 and Nonsense-Mediated mRNA Decay (NMD).

The Complex Relationship between HTLV-1 and Nonsense-Mediated mRNA Decay (NMD).

Léa Prochasson, Pierre Jalinot, and Vincent Mocquet (2020)

Pathogens, 9(4).

Before the establishment of an adaptive immune response, retroviruses can betargeted by several cellular host factors at different stages of the viralreplication cycle. This intrinsic immunity relies on a large diversity ofantiviral processes. In the case of HTLV-1 infection, these active innate hostdefense mechanisms are debated. Among these mechanisms, we focused on an RNAdecay pathway called nonsense-mediated mRNA decay (NMD), which can targetmultiple viral RNAs, including HTLV-1 unspliced RNA, as has been recentlydemonstrated. NMD is a co-translational process that depends on the RNA helicaseUPF1 and regulates the expression of multiple types of host mRNAs. RNAsensitivity to NMD depends on mRNA organization and the ribonucleoprotein (mRNP)composition. HTLV-1 has evolved several means to evade the NMD threat, leading toNMD inhibition. In the early steps of infection, NMD inhibition favours theproduction of HTLV-1 infectious particles, which may contribute to the survivalof the fittest clones despite genome instability; however, its direct long-termimpact remains to be investigated.

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