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Sperm chromatin remodeling at fertilization

Drosophila is an excellent model to study the mechanisms involved in the genome-wide replacement of sperm SNBPs with maternally supplied histones. Our team has pioneered research on this theme through the discovery of the essential role played by the HIRA histone chaperone during sperm chromatin remodeling (Loppin et al., Nature, 2005). We are pursuing this task aimed at identifying new egg factors required for the integration of paternal chromosomes in the diploid zygote.