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Michelle D. Wang — DNA Accessibility in Nucleosomes

Speaker :

Michelle D. Wang, Department of Physics, Howard Hughes Medical Institute, Cornell University

When :

Monday 5 July at 16h

Where :

C023 (RDC LR6 côté Centre Blaise Pascal)

Title :

DNA Accessibility in Nucleosomes

Abstract :

The cell nucleus is a highly dynamic reaction center for many DNA-based cellular processes, as well as an effective compaction center for DNA storage. The basic packing unit of chromatin is the nucleosome. Even this lowest level of genomic compaction presents a strong barrier to many DNA-binding cellular factors. In a coordinated and regulated fashion, DNA associated with nucleosomes must be made transiently accessible to permit many essential processes. Nucleosome stability and structure thus are intimately involved in the regulation of genetic information storage and retrieval. Single molecule mechanical studies are ideally suited to probe these processes and have become powerful complementary tools to traditional biochemical and molecular biological approaches. I will discuss our progress in mechanical studies of nucleosome stability and structure, as well as how DNA in nucleosomes may be accessed by motor proteins.

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