Accueil du site > Animations Scientifiques > Séminaires 2010 > Oliver Rando — Fungal chromatin dynamics : from 15 minutes to one billion years
Oliver Rando — Fungal chromatin dynamics : from 15 minutes to one billion years
Speaker :
Oliver Rando, University of Massachusetts Medical School
When :
Monday 5 July at 17h
Where :
C023 (RDC LR6 côté Centre Blaise Pascal)
Title :
Fungal chromatin dynamics : from 15 minutes to one billion years
Abstract :
Our laboratory uses genome-wide mapping techniques to study the role of chromatin structure in transcriptional control and epigenetic inheritance in fungi. Here, I will present two ongoing efforts in our lab. In the first, we take a comparative genomics approach to nucleosome positioning, and characterize the genome-wide positions of nucleosomes in 14 fungal species spanning a billion years of evolution. In the second, we use two different pulse-chase techniques to measure the dynamics behavior of nucleosomes in budding yeast. We characterize replication-independent histone replacement, and subsequently follow how nucleosomes behave during genomic replication. Our results have interesting implications for the evolution of gene regulation, the role of sequence in nucleosome positioning, and the plausibility of chromatin as a carrier of epigenetic information.
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