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You are here: Home / Teams / Physical Biology of Chromatin - D. Jost / Publications / Chromosome dynamics during interphase: a biophysical perspective.

Chromosome dynamics during interphase: a biophysical perspective.

Maxime M Tortora, Hossein Salari, and Daniel Jost (2020)

Curr Opin Genet Dev, 61:37-43.

The dynamic nature of chromosome organization plays a central role in the regulation of many crucial processes, such as DNA transcription and replication.However, the molecular bases of the link between genomic function, structure anddynamics remain elusive. In this review, we focus on how biophysical modelling can be instrumentally used to rationalize experimental studies of chromosome dynamics, and to probe the impact of putative mechanisms on genome folding kinetics during interphase. We introduce the general connection between chromatin internal organization and dynamics, and outline the potential effects of passiveinteractions mediated by architectural proteins and of active, energy-dependent processes on chromatin motion. Finally, we discuss current ambiguities emerging from in vivo observations, in particular related to ATP depletion and transcriptional activation, and highlight future perspectives.

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