The folding of interphase chromatin fibres into mitotic chromosomes is acknowledged as a prerequisite for the faithful transmission of genetic and epigenetic information through cell divisions. Yet, the mechanisms by which mitotic chromosomes assemble upon mitotic entry, and disassemble upon mitotic exit, remain poorly understood. Recent advances in experimental techniques coupled with fruitful collaborations with theorists have revealed key structural and mechanistic aspects. However, a complete understanding of the structural and functional changes undergone by the genome as cells proceed through mitosis will require contributions from a broad spectrum of soft-condensed matter physics, such as polymer/polyelectrolyte physics, sol-gel phase transition, surfactant self-assembly, active matter, material elasticity, etc...
This Mitotic Chromosome Workshop (organized by the GDR ADN&G, Lab Phys, LBMC, Cecam-FR-RA) aims to stimulate future experimental and theoretical research and collaborations in this area by bringing together experimentalists and theoreticians. The oral presentations will review the current knowledge and outline the various obstacles to be overcome in the future. We hope that this will fuel open and insightful discussions and open new perspectives on interdisciplinary research in this area.
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