Partenaires
Rechercher
Accueil du site > Animations Scientifiques > Séminaires 2010 > Antonin Morillon — Regulatory non coding (nc)RNA and epigenetic in yeast
Antonin Morillon — Regulatory non coding (nc)RNA and epigenetic in yeast
Orateur :
Antonin Morillon, Institut Curie, Paris
Quand :
Mercredi 3 mars à 11h
Où :
C023 (RDC LR6 côté Centre Blaise Pascal)
Title :
Regulatory non coding (nc)RNA and epigenetic in yeast
Abstract :
Noncoding (nc)RNAs produced within the S. cerevisiae genome can be divided into SUTs (Stable Unannotated Transcripts) and CUTs (Cryptic Unstable Transcripts), which mostly initiate from Nucleosome-Free Regions associated with the promoters of divergent mRNA transcripts. Recent data show the first examples in budding yeast of trans-acting regulatory ncRNA controlling transposon mobility and /PHO84/ gene expression. To generalize this observation, we used RNA-SEQ to identify an entire novel class of ncRNAs, containing mostly uncharacterized transcripts and encompassing some CUTs and SUTs. Interestingly, certain of those ncRNA show a regulatory potential that requires the Set1C/COMPASS methyltransferase complex, responsible of the H3K4me2/3 deposition, to repress gene expression. We speculate that our data support a model in which certain yeast promoters are controlled by cryptic or noncoding transcripts through chromatin modifications.
Dans la même rubrique :
- Olivier Gandrillon — A system’s biology approach to understand stochasticity in gene expression
- François Graner — Dynamique des matériaux cellulaires : l’exemple des mousses
- Eric Clément —
- Jacques Pecreaux — Doing the spindle rock. Mitotic spindle motion in C elegans one-cell embryo.
- Arach Goldar — Measuring the time dependent rate of replication origin activation in a single {Saccharomyces cerevisiae} cell by using population dynamics
- Gijsje Koenderink — Active self-organization of the actin cytoskeleton driven by molecular motors
- M. Carmen Romano — Traffic dynamics of translation : modelling the synthesis of proteins
- Michael Lässig — Molecular evolution in fitness landscapes and seascapes
- Ala Trusina — Defining Network Topologies that Can Achieve Biochemical Adaptation
- George Reid —
- Malcolm Buckle — Etude cinétique et dynamique des complexes macromoléculaires impliquées dans la régulation de l’expression génique par la résonance des plasmons de surface
- Anne-Marie Tassin — Procentriole assembly revealed by cryo-electron tomography
- André Estévez-Torres — Synthetic epigenetics : Sequence-independent photocontrol of gene expression in vitro
- Olivier Cuvier — Deciphering the Discrete Stages of Insulator-encoded Nucleosome-Positioning : The Road towards Transcriptional Competence
- Nick Gilbert — Effect of DNA supercoiling on chromatin structures
- Aurélien Rappailles — Genome wide study of Human DNA replication
- Christophe Lavelle — Chromatin : the DNA manager (and vice versa)
- Michelle D. Wang — DNA Accessibility in Nucleosomes
- Oliver Rando — Fungal chromatin dynamics : from 15 minutes to one billion years
- Shixin Ye — Application of site-directed mutagenesis with unnatural amino acids in studies of G protein-coupled receptors
