Partenaires
Rechercher
Accueil du site > Animations Scientifiques > Séminaires 2010 > André Estévez-Torres — Synthetic epigenetics : Sequence-independent photocontrol of gene expression in vitro
André Estévez-Torres — Synthetic epigenetics : Sequence-independent photocontrol of gene expression in vitro
Speaker :
André Estévez-Torres, Physics Department, Princeton University and Laboratorie de photonique et de nanostructures, CNRS, Marcoussis
When :
Wednesday 20 October at 11am
Where :
C023 (RDC LR6 côté Centre Blaise Pascal)
Title :
Synthetic epigenetics : Sequence-independent photocontrol of gene expression in vitro
Abstract :
My goal is to understand biological functions from the point of view of chemical reactions. To this end, I take the approach of developing minimal synthetic models that capture basic features. Here, I will introduce a simple attempt to explain the correlation between DNA compaction and gene expression level in prokaryotes. Our approach resulted in a method to control gene expression in vitro using light. Instead of relying on specific interactions, it uses a photo-induced conformational transition of nucleic acids and has the unique advantage of being, at once, reversible and independent of the sequence and the length of a given nucleic acid. Our results indicate that the accessibility of the protein machinery to one or several binding sites can be efficiently regulated by changing nucleic acid conformation.
Dans la même rubrique :
- Olivier Gandrillon — A system’s biology approach to understand stochasticity in gene expression
- François Graner — Dynamique des matériaux cellulaires : l’exemple des mousses
- Eric Clément —
- Jacques Pecreaux — Doing the spindle rock. Mitotic spindle motion in C elegans one-cell embryo.
- Arach Goldar — Measuring the time dependent rate of replication origin activation in a single {Saccharomyces cerevisiae} cell by using population dynamics
- Gijsje Koenderink — Active self-organization of the actin cytoskeleton driven by molecular motors
- M. Carmen Romano — Traffic dynamics of translation : modelling the synthesis of proteins
- Antonin Morillon — Regulatory non coding (nc)RNA and epigenetic in yeast
- Michael Lässig — Molecular evolution in fitness landscapes and seascapes
- Ala Trusina — Defining Network Topologies that Can Achieve Biochemical Adaptation
- George Reid —
- Malcolm Buckle — Etude cinétique et dynamique des complexes macromoléculaires impliquées dans la régulation de l’expression génique par la résonance des plasmons de surface
- Anne-Marie Tassin — Procentriole assembly revealed by cryo-electron tomography
- Olivier Cuvier — Deciphering the Discrete Stages of Insulator-encoded Nucleosome-Positioning : The Road towards Transcriptional Competence
- Nick Gilbert — Effect of DNA supercoiling on chromatin structures
- Aurélien Rappailles — Genome wide study of Human DNA replication
- Christophe Lavelle — Chromatin : the DNA manager (and vice versa)
- Michelle D. Wang — DNA Accessibility in Nucleosomes
- Oliver Rando — Fungal chromatin dynamics : from 15 minutes to one billion years
- Shixin Ye — Application of site-directed mutagenesis with unnatural amino acids in studies of G protein-coupled receptors
