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Michael Lässig — Molecular evolution in fitness landscapes and seascapes
Speaker :
Michael Lässig, Statistical Physics and Quantitative Biology, Institute for Theoretical Physics, University of Cologne
When :
Wednesday 16 June at 11h
Where :
C023 (RDC LR6 côté Centre Blaise Pascal)
Title :
Molecular evolution in fitness landscapes and seascapes
Abstract :
In modern biology, an important challenge is to link genomic data to molecular functions of an organism. Individual parts contributing to a common function depend on each other, and this leads to interactions in fitness and evolution. In this talk, we discuss fitness landscapes for specific molecular functions, which demonstrate the link between their biophysics and their evolution. Examples include fitness landscapes for transcriptional regulation and for processing of micro-RNA molecules. Based on these examples, we address some fundamental questions on fitness landscapes : How does natural selection correlate the evolution of parts contributing the same function ? Conversely, what determines modularity in the evolution of an organism, that is, the independence of different functions ? When can we think of molecular evolution as dynamics in a static fitness landscape, and when is selection itself a dynamic fitness seascape ?
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