Accueil du site > Animations Scientifiques > Séminaires 2010 > Michelle D. Wang — DNA Accessibility in Nucleosomes
Michelle D. Wang — DNA Accessibility in Nucleosomes
Speaker :
Michelle D. Wang, Department of Physics, Howard Hughes Medical Institute, Cornell University
When :
Monday 5 July at 16h
Where :
C023 (RDC LR6 côté Centre Blaise Pascal)
Title :
DNA Accessibility in Nucleosomes
Abstract :
The cell nucleus is a highly dynamic reaction center for many DNA-based cellular processes, as well as an effective compaction center for DNA storage. The basic packing unit of chromatin is the nucleosome. Even this lowest level of genomic compaction presents a strong barrier to many DNA-binding cellular factors. In a coordinated and regulated fashion, DNA associated with nucleosomes must be made transiently accessible to permit many essential processes. Nucleosome stability and structure thus are intimately involved in the regulation of genetic information storage and retrieval. Single molecule mechanical studies are ideally suited to probe these processes and have become powerful complementary tools to traditional biochemical and molecular biological approaches. I will discuss our progress in mechanical studies of nucleosome stability and structure, as well as how DNA in nucleosomes may be accessed by motor proteins.
Dans la même rubrique :
- Olivier Gandrillon — A system’s biology approach to understand stochasticity in gene expression
- François Graner — Dynamique des matériaux cellulaires : l’exemple des mousses
- Eric Clément —
- Jacques Pecreaux — Doing the spindle rock. Mitotic spindle motion in C elegans one-cell embryo.
- Arach Goldar — Measuring the time dependent rate of replication origin activation in a single {Saccharomyces cerevisiae} cell by using population dynamics
- Gijsje Koenderink — Active self-organization of the actin cytoskeleton driven by molecular motors
- M. Carmen Romano — Traffic dynamics of translation : modelling the synthesis of proteins
- Antonin Morillon — Regulatory non coding (nc)RNA and epigenetic in yeast
- Michael Lässig — Molecular evolution in fitness landscapes and seascapes
- Ala Trusina — Defining Network Topologies that Can Achieve Biochemical Adaptation
- George Reid —
- Malcolm Buckle — Etude cinétique et dynamique des complexes macromoléculaires impliquées dans la régulation de l’expression génique par la résonance des plasmons de surface
- Anne-Marie Tassin — Procentriole assembly revealed by cryo-electron tomography
- André Estévez-Torres — Synthetic epigenetics : Sequence-independent photocontrol of gene expression in vitro
- Olivier Cuvier — Deciphering the Discrete Stages of Insulator-encoded Nucleosome-Positioning : The Road towards Transcriptional Competence
- Nick Gilbert — Effect of DNA supercoiling on chromatin structures
- Aurélien Rappailles — Genome wide study of Human DNA replication
- Christophe Lavelle — Chromatin : the DNA manager (and vice versa)
- Oliver Rando — Fungal chromatin dynamics : from 15 minutes to one billion years
- Shixin Ye — Application of site-directed mutagenesis with unnatural amino acids in studies of G protein-coupled receptors