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Accueil du site > Animations Scientifiques > Séminaires 2010 > Olivier Cuvier — Deciphering the Discrete Stages of Insulator-encoded Nucleosome-Positioning : The Road towards Transcriptional Competence
Olivier Cuvier — Deciphering the Discrete Stages of Insulator-encoded Nucleosome-Positioning : The Road towards Transcriptional Competence
Speaker :
Olivier Cuvier, Cell Cycle Chromosome Dynamics Group, LBME, CNRS-University P. Sabatier, Toulouse
When :
Wednesday 28 April at 11am
Where :
C023 (RDC LR6 côté Centre Blaise Pascal)
Title :
Deciphering the Discrete Stages of Insulator-encoded Nucleosome-Positioning : The Road towards Transcriptional Competence
Abstract :
Recent breakthrough in the chromatin field was to show that nucleosomes are specifically positioned near transcription start sites, underlying mechanisms that remain to be fully described. Nucleosome-positioning appears to be tightly linked to actively transcribing genes. Our ChIP-seq data show that insulators, which have been involved in regulating gene expression by opening chromatin structure, may in fact tightly regulate discrete stages of transcription. Novel statistical analysis by clustering approaches highlight the roles of insulator co-factors at multiple discrete stages of transcription including promoter escape. Insulators appear to regulate nucleosome occupancy at specific positions including +1 and +2. The code for such positioning may be tightly linked to the binding of several distinct insulator co-factors and to the assembly of higher-order chromatin structure. Our data decipher key mechanisms linking nucleosome-positioning to specific stages of transcription that are regulated by insulators.
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