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Véronique Rosilio — Molecular organized films of lipids, proteins and amphiphilic polymers : Application to innovative pharmaceutical systems.
Speaker :
Véronique Rosilio, Physico-Chimie des Surfaces, UMR 8612 CNRS-Université Paris-Sud
When :
Wednesday 9 February at 11am
Where :
C023 (RDC LR6 côté Centre Blaise Pascal)
Title :
Molecular organized films of lipids, proteins and amphiphilic polymers : Application to innovative pharmaceutical systems.
Abstract :
For the last four decades, innovative strategies have been developed to prolong and control drug release, produce long-circulating nano-carriers or target specific cell membrane receptors. These strategies often involve the use of amphiphilic polymers, to form drug delivery systems (matrix, capsule, emulsion), modify carrier characteristics (stability and stealth properties) or solubilize a drug. Ligands are added to improve specificity. Although size reduction of a drug delivery system has several advantages, it also generates significant increase in surface area, and thus, development of multiple favorable/unfavorable interactions with the surrounding medium.
The theoretical approach and technical tools of surface physical chemistry can provide information on the mechanisms of formation of these systems, their stability but also their behavior in biological fluids. Combination of surface tension, surface pressure, surface potential and QCM-D measurements in controlled conditions yields quantitative data giving a better insight into molecular organization and nonspecific/specific interactions at interfaces. Using this approach, we have studied the effect of amphiphilic polysaccharides on the formation and stabilization of drug carriers, and solubilization of proteins and drugs. We have also built lipid-lectin and lipid-lipopolysaccharide monolayers/bilayers mimicking biological membranes, and studied the interaction of potential drug systems with them.
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