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Accueil du site > Animations Scientifiques > Séminaires 2011 > Saadi Khochbin — Molecular basis of post-meiotic male genome reprogramming : essential role for histone hyperacetylation and histone variants
Saadi Khochbin — Molecular basis of post-meiotic male genome reprogramming : essential role for histone hyperacetylation and histone variants
Speaker :
Saadi Khochbin, Institut Albert Bonniot, Grenoble
When :
Wednesday 6 April at 11am
Where :
C023 (RDC LR6 côté Centre Blaise Pascal)
Title :
Molecular basis of post-meiotic male genome reprogramming : essential role for histone hyperacetylation and histone variants
Abstract :
In mammals, post-meiotic male genome reorganization and compaction could be considered as conceptually related to sporulation in lower eukaryotes or pollen formation in plants all involving the preparation of the genome to confront the hostile exterior environment. All involve genome compaction mechanisms of completely unclear nature. In mammals, the current knowledge implies a post-meiotic stepwise replacement of histones by transition proteins and protamines to finally pack the genome into the mature spermatozoid. Our investigations have already highlighted the existence of another level of organization involving new testis-specific histone variants, which are specifically incorporated in pericentric regions, when canonical histones are removed. We suggest that these histones are the actors of a general post-meiotic reprogramming process that directs the packaging of specific genomic regions in differentiated structures and mark their identity in the fully packed genome of mature spermatozoa. Furthermore, we propose here that the wave of genome-wide histone acetylation that occurs at the beginning of the spermatid elongation triggers the subsequent post-meiotic reprogramming process leading to histone replacement and regional differentiation of various genomic regions. An essential factor mediating these histone acetylation-dependent events has been identified in our laboratory and the molecular basis of its action will be presented and discussed.
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