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Accueil du site > Animations Scientifiques > Séminaires 2013 > Manouk Abkarian - Elastic prison break of malaria parasites : how to use the physics of the gift ribbon
Manouk Abkarian - Elastic prison break of malaria parasites : how to use the physics of the gift ribbon
Speaker : Dr. Manouk Abkarian - CNRS Research Associate - Laboratoire Charles Coulomb UMR 5221 CNRS-UM2 - Département Colloïdes, Verres et Nanomatériaux - Université Montpellier 2
When : thursday 23 rd May at 11 am
Where : Salle CO23 (grande salle de réunions du CBP rez-de-chaussée LR6)
Title :Elastic prison break of malaria parasites : how to use the physics of the gift ribbon
The culminating step of the intra-erythrocytic development of P. falciparum, the causative agent of malaria, is the spectacular release of multiple invasive merozoites upon rupture of the infected erythrocyte membrane, and remains up to now an intriguing and controversial process because of its ephemeral nature. In this presentation, I will report that the whole process, taking place in time scales as short as 400 ms, is the result of an elastic instability of the infected erythrocyte membrane. Using high-speed DIC video-microscopy and epifluorescence, I will demonstrate that the release occurs in three main steps following osmotic swelling of the infected erythrocyte : a pore opens in about 100 ms, ejecting 1-2 merozoites, an outward curling of the erythrocyte membrane is then observed, ending by a fast snap-buckling eversion of the infected erythrocyte membrane, pushing the parasites forward. I will rationalize these observations by considering that during the parasite development the infected red blood cell membrane acquires a spontaneous curvature and I will present a subsequent model describing the dynamics of the curling rim analogous to the physics of the gift ribbon. These results show that sequential red blood cell membrane curling and buckling is necessary for the parasites efficient angular dispersion and might be biologically primordial for fast and numerous invasions of new erythrocytes.
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