Skip to content. | Skip to navigation

Personal tools

Sections
Logo ENS Logo CNRS
Logo UCBL Logo Inserm
You are here: Home

Laboratoire de Biologie et Modélisation de la Cellule - UMR 5239 - Inserm 1293

The LBMC is an experimental biology laboratory hosted at ENS de Lyon in a multidisciplinary scientific environment. The laboratory's main subject of study is the cell, which is the most fundamental unit of life.

The 15 research teams aim at integrating diverse aspects of cell life such as proliferation, differentation, and interaction with cellular environment in a normal or pathogenic context. The fundamental research pursued in the laboratory relies on expertise in cellular and molecular biology and integrates interdisciplinary approaches in (bio)computing, (bio)physics and (bio)mathematics.

More details here.

Follow us on Twitter @Lyon_LBMC

Last publications
2026 Rojat V & al, Nature communications Automated mapping of DNA replication fork (...)
2026 D’Asaro D & al, Nucleic Acids Research Modeling the spatial organization of replicated (...) F (...)
2026 Dufour A & al, Biol Open Kinetic properties of optogenetic site-specific (...) A (...)
2026 Giorgetti L & Jost D, Current opinion in genetics & development Editorial overview: Genome Architecture and (...)
2026 Dufour A & al, Biol Open Kinetic properties of optogenetic site-specific (...) A (...)
2026 Cheutin T & al, Cell Discov PRC1 nanoglobules organize Hox chromatin during (...) P (...)
2026 Akilli N & al, Nucleic Acids Res Loss of SUMOylation drives aberrant PRC1 (...) P (...)
2026 Piveteau V & al, EMBO J Condensin loop extrusion properties, roadblocks, (...) T (...)
2025 Lüthi B & al, Nat Commun Cohesin forms fountains at active enhancers in C. (...) T (...)
2026 Paldi F & al, Nat Genet Transient histone deacetylase inhibition induces (...) E (...)
2025 D’Asaro D & al, Genome Biology Genome-wide modeling of DNA replication in space (...)
2026 Duharcourt S & al, Nat Rev Genet The mechanistic and evolutionary diversity of (...) B (...)
News
Teams
Artificial Intelligence for Single-Cell Data Analysis (SCAI)
Lorem ipsum dolor sit amet, consectetur adipiscing elit. Vivamus volutpat purus a bibendum (...) Read more
Chromatin Architecture in Replication and Repair (CARR)
DNA double-strand breaks (DSBs) and replication stress are major threats to genome integrity that (...) Read more
Dynamics and Control of Biological Assemblies and Macromolecular Machines
We are a horizontal team of four researchers in computational biology. We study molecular machines (...) Read more
Complexity, plasticity, and functionality of miRNAs
We elucidate the mechanism of modular layer of post-transcriptional control formed by miRNAs, which (...) Read more
Genome mechanics
DNA is a busy molecule teeming with a zoo of static binders and molecular motors. DNA's (...) Read more
Physical Biology of Chromatin
In close connection with experimental biology, our research addresses generic or specific (...) Read more
Epigenetics and Zygote Formation
The formation of a diploid zygote from two highly different gametes is a critical aspect of sexual (...) Read more
RNA metabolism in immunity and infection (RMI2)
We are interested in post-transcriptional control mechanisms that regulate gene expression in cells (...) Read more
Genetic Complexity of Living Systems
Our research group is interested in the fundamental genetic mechanisms underlying inter-individual (...) Read more
Unconventional modes of DNA maintenance and transmission
We investigate unconventional modes of DNA transmission and genome regulation, exploring their (...) Read more
Regulated Cell Death and Genetics of Neurodegeneration
The general goal of our lab is to understand the mechanisms of cell death, ER stress, autophagy and (...) Read more
Regulation of Genome Architecture and Dynamics of Splicing (ReGArDS)
Our team is interested in the regulation of alternative splicing, the main process allowing to (...) Read more
Comparative and Integrative Genomics of Organ Development
We compare genomes and transcriptomes to highlight general rules about the development and/or the (...) Read more
Posttranscriptional Regulation in Infection and Oncogenesis
Our main research interest is to decipher the molecular mechanisms underlying oncogenesis, with a (...) Read more
Epithelial differentiation and morphogenesis in Drosophila
Read more
Systems Biology of Decision Making
The molecular mechanisms controlling decision making at the cellular level between self-renewal and (...) Read more
Chromatin Dynamics in Mitotic Chromosome Assembly
The ability of the genome to adopt a dynamic 3D organisation underlies most DNA transactions. The (...) Read more
 
 
Seminars
Oct 23, 2026
Benoit SAMSON
Disentangling Cell Abundance and Gene Expression Reveals Spatial Heterogeneity in Pituitary Tumours
Oct 30, 2026
Kai STROH
Targeted Protein Degradation
Nov 06, 2026
GUEST
Nov 13, 2026
EQ WORM
Past thesis defenses