The folding of chromosomes inside the cell nucleus plays an essential role in the regulation of genome functions. However, the underlying biological and physico-chemical mechanisms are still poorly understood, empeding any reliable quantitative predictions of genome organisation and activity changes when subject to perturbations or diseases. "3D Genomics" addresses such questions and now represents a booming field due to the recent development of high-resolution and high-throughput experimental approaches. Due to the inherent complexity of experimental data, this domain of biology benefits greatly from physical modelling and statistical data analyses. During the last decade, spectacular advances in the understanding of the coupling between genome structure and functions have been obtained thanks to the interaction of these different scientific disciplines. This school aims at enhancing such interdisciplinary communication by training the next generation of researchers in 3D Genomics to state-of-the-art experimental, modelling, numerical and data analysis approaches.