CHIM4108 : Principes de base de la RMN

This course is aimed at students who already have some familiarity with NMR spectroscopy, and who wish to deepen their understanding of how NMR experiments actually ‘work’.  We concentrate on the description of common experiments, and explain in detail the their behind these experiments.  The quantum mechanical tools needed to analyse pulse sequences and introduced step by step, and are then applied to a series of one-dimensional and two-dimensional NMR experiments (COSY, DQF-COSY, TOSCY, DQ spectroscopy, INEPT, HSQC, HMQC, HMBC).  Finally, we introduce the quantum mechanical tools needed for understanding electronic spins, and how they are observed by EPR spectroscopy.

Plan du cours

• Introduction to NMR spectroscopy
• Energy levels and NMR spectra
• The vector model of pulsed NMR and pulse sequences
• Introduction to relaxation
• Fourier transformation and NMR
• The quantum mechanics on one nuclear spin
• Product operators
• Two-dimensional NMR (COSY, DQF-COSY, TOSCY, DQ spectroscopy, INEPT, HSQC, HMQC, HMBC)
• EPR