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Accueil du site > Animations Scientifiques > Séminaires 2007 > Electron-donor modified nanoparticles for selected cell labeling and photodynamic therapy
Electron-donor modified nanoparticles for selected cell labeling and photodynamic therapy
par Webmaster - 21 novembre 2007
Orateur :
Jay Nadeau, Department of Biomedical Engineering, McGill University, Montreal, Canada
Salle :
Electron-donor modified nanoparticles for selected cell labeling and photodynamic therapy
Sujet :
Electron donors conjugated to semiconductor nanoparticles (quantum dots or QDs) have particular photophysical properties that make them interesting for the creation of biosensors and therapeutic agents. First, the transfer of an electron into the QD valence band eliminates exciton recombination, thus turning off the QD fluorescence in the presence of the donor. Interactions of the donor with cellular receptors or other structures may alter its redox properties, thus restoring QD fluorescence and providing a visible signal of processing within the cell. Second, QDs modified in such a way are photosensitized—that is, the exciton electron is free to transfer to other molecules, including oxygen. This leads to the formation of reactive oxygen species and cytotoxicity. This may be used to develop specific agents for targeting killing of cancer cells and/or pathogenic bacteria and fungi.
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