During the COVID-19 pandemic, Multisystem Inflammatory Syndrome in Children (MIS-C) affected 1,100 children. This is the most severe form of COVID-19-associated disease in pediatric patients. Since this first description in 2020, researchers from the Centre International de Recherche en Infectiologie (CIRI - Inserm/CNRS/ENS de Lyon/Université Claude Bernard Lyon 1) and clinicians from the Hospices Civils de Lyon, in collaboration with the Amsterdam UMC, the Hamad Bin Khalifa University in Doha (Qatar), the Imagine Research Institute (Necker-Enfants malades AP-HP hospital), the Rockefeller Institute in New York, the Nice University Hospial (CHU de Nice) and other international collaborators, have discovered that this syndrome existed before COVID-19, and that other infectious agents could lead to this severe inflammatory syndrome in children. The results are published in the New England Journal of Medicine.

Reference
Pre–Covid-19, SARS-CoV-2–Negative Multisystem Inflammatory Syndrome in Children. Benezech S°, Khoryati L°, Cognard J, Netea S, Khan T, Moreews M, Saker K, De Guillebon JM, Khaldi-Plassart S, Pescarmona R, Viel S, Malcus C, Perret M, Ar Gouilh M, Vabret A, Venet F, Remy S, Chopin E, Lina G, Vandenesch F, Rousseaux N, Bastard P, Zhang SY, Casanova JL, Trouillet-Assant S, Walzer T, Kuijpers T, Javouhey E, Dauwalder O, Marr N, Belot A. N Engl J Med, November 30, 2023.
DOI : 10.1056/NEJMc2307574

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