CNRS Medals 2024: congratulations to the silver and bronze medallists from ENS de Lyon Thu, 22/02/2024 Honors and awards The CNRS awards François Leulier, Director of the IGFL, the silver medal and Lucie Étienne, a researcher at CIRI, and three alumni of our school, the bronze medal. Article
COVID-19: Multisystem Inflammatory Syndrome in Children (MIS-C) existed before the pandemic Mon, 04/12/2023 Press release, Publication Publication of the CIRI in the New England Journal of Medicine on November 30, 2023. Press release of Claude Bernard Lyon 1 University on November 30, 2023. Article
Biosantexc: Get-together at ENS de Lyon Mon, 30/10/2023 News In the framework of the BIOSANTEXC project, the Office of International Affairs of ENS de Lyon hosted a get-together on October 5th to welcome interns and visiting professors from the IISERs. Article
Biosantexc – Official kick-off meeting of the project Mon, 22/05/2023 A delegation from ENS de Lyon, composed of the Office of International Affairs and representatives of the four laboratories in life sciences of the ENS de Lyon, will be present at the IISER Pune, where this important moment of the Biosantexc project will take place form May 23 to May 25, 2023. Article
Covid-19: infection-vaccination combination best protects against reinfection with SARS-CoV-2 Thu, 23/03/2023 Press release, Publication Publication of the CIRI in the journal Science Translational Medicine on March 15, 2023. Press realease of the INSERM on March 17, 2023. Article
Abdelrahim Zoued, researcher at CIRI, receives the Jacques Monod Foundation Prize Wed, 01/03/2023 Honors and awards CNRS researcher at CIRI since February 1st, 2023, Abdelrahim Zoued works on the Legionella pneumophila bacterium. He received the Jacques Monod Foundation 2022 Prize, awarded by the Fondation de France, for his research project on the pathogen-host interface during infections. Article
Development of a pentavalent vaccine against New World arenaviruses Tue, 17/01/2023 Publication Publication of the CIRI in the journal Nature Microbiology on January 5, 2023. Communication of the Institut Pasteur on January 6, 2023. Article
How can bats harbor so many viruses without developing symptoms? Mon, 28/11/2022 Press release, Publication Publication of the CIRI in the journal Science Advances on November 23, 2022. CNRS press alert on November 23, 2022. Article
YAP, protein involved in staphylococcus aureus infections, opens the door to new therapeutic strategies Mon, 28/11/2022 Press release, Publication Publication of the CIRI in the journal Nature Communications on November 16, 2022. Jean Monnet University press release on November 28, 2022. Article
Steroid hormone metabolites activate the pyrin inflammasome Fri, 25/11/2022 Publication Publication of the CIRI in the journal Cell Reports on October 11, 2022. CNRS-INSB communication on November 7, 2022. Article
Lessons from Covid-19: a detailed roadmap to improve One Health approaches is available at last Fri, 28/10/2022 Press release, Publication Publication of the French Scientific Council on Covid-19 in the journal The Lancet on October 24, 2022. CIRAD press release on October 26, 2022. Article
At what stage(s) after infection are memory CD8 T cells generated? Fri, 23/09/2022 Publication Publication of the CIRI and the LBMC in the journal iScience on September 16, 2022. CNRS-INSB communication on September 22, 2022. Article
COVID-19: Keys to the disease in the past of primate and bat genes? Thu, 08/09/2022 Publication Publication of the CIRI in the journal PNAS on August 10, 2022. CNRS-INSB communication on September 7, 2022. Article
Defeating viruses by targeting metabolism and antiviral immunity Fri, 15/04/2022 News News on the VIRIMI team (Viral Infection, Metabolism and Immunity) of CIRI. Communication by the CNRS Foundation on April 14, 2022. Article
Covid-19 - Towards a vaccination strategy adapted to immunosuppressed patients Mon, 28/02/2022 News, Publication Publication of the CIRI in the journal Science Translational Medicine on February 1st, 2022. Claude Bernard Lyon 1 University focus on February 24, 2022. Article
Antibiotic resistance: how some bacteria capture resistance genes from their environment? Tue, 08/02/2022 Press release, Publication Publication of the CIRI in the journal mBio on January 25, 2022. vetAgroSup and Iserm Press release on February 7, 2022. Picture credits: solarsevn Article
François-Loïc Cosset, recipient of the Jaffé Prize - Institut de France Wed, 24/11/2021 Honors and awards This prize is awarded for work intended for the progress and well-being of humanity. Article
NLRP3 phosphorylation in its LRR domain critically regulates inflammasome assembly Fri, 08/10/2021 Publication CIRI publication in Nature Communications on October 6, 2021. Article
Hamster organotypic modeling of SARS-CoV-2 lung and brainstem infection Fri, 08/10/2021 Publication CIRI publication in Nature Communications on 4 Octobre, 2021. Article
Early nasal type I IFN immunity against SARS-CoV-2 is compromised in patients with autoantibodies against type I IFNs Thu, 05/08/2021 Publication Publication of CIRI in Journal of Experimental Medicine. Communication from Lyon Hospitals on August 5, 2021. Article
The ROMANOV study found impaired humoral and cellular immune responses to SARSCov-2 mRNA vaccine in virus unexposed patients receiving maintenance hemodialysis Tue, 20/07/2021 Publication Publication of CIRI in the journal Kidney International on July 17, 2021. Article
Structural insight into SARS-CoV-2 neutralizing antibodies and modulation of syncytia Fri, 04/06/2021 Publication Publication by CIRI in the journal Cell on April 23, 2021. Article
Massive clonal expansion of polycytotoxic skin and blood CD8+ T cells in patients with toxic epidermal necrolysis patients Mon, 22/03/2021 Publication Publication of CIRI in Sciences advances on March 19, 2021. Article
CNRS 2021 bronze and silver medals: a good track record Mon, 22/03/2021 Honors and awards Congratulations to Olivier Terrier, research fellow at CIRI, recipient of the CNRS Bronze Medal for 2021. Article
Loop extrusion as a mechanism for formation of DNA damage repair foci Fri, 19/02/2021 Publication Publication of CIRI and LBMC in Nature on February 17, 2021. Article
Ultrastructural modifications induced by SARS-CoV-2 in Vero cells: a kinetic analysis of viral factory formation, viral particle morphogenesis and virion release Fri, 15/01/2021 Publication Publication of CIRI in the journal Cellular and Molecular Life Sciences on January 15, 2021. Article
Neonatal sepsis: antibiotic resistance causing worldwide spread Thu, 14/05/2020 Publication by CIRI in the journal Nature microbiology on April 27, 2020. Article
Interferon-alpha deficiency in covid-19 patients: new therapeutic perspectives Wed, 06/05/2020 Publication Publication by CIRI in The Journal of Allergy and Clinical Immunology, on April 24, 2020. Article
Six new research projects concerning Covid-19 Mon, 04/05/2020 News On April 10, 2020, ANR announced the funding of 86 projects concerning Covid-19. Six are associated with ENS de Lyon laboratories. Image credit ©Institut Pasteur Article
Covid-19: CIRI mobilizes its teams to understand the immune response against Coronavirus in patients Wed, 15/04/2020 News A CIRI project, in collaboration with HCL, has united CIRI immunologists to work on understanding the immune response to Coronavirus in patients. Article
ENS de Lyon gives HCL a hand Wed, 15/04/2020 News The research laboratories of ENS de Lyon are continuing to support hospitals and public services that are on the front line of the health crisis. Article
ENS de Lyon steps into action to help the HCL hospitals Tue, 31/03/2020 News The research laboratories of ENS de Lyon are helping support hospitals and public services that are on the front line of the health crisis. Article
Menstrual Toxic Shock: instructions for use of tampons to limit the risk Tue, 17/03/2020 Publication CNRS press release on March 10, 2020. Article
Missing self triggers NK cell-mediated chronic vascular rejection of solid organ transplants Mon, 25/11/2019 Publication Publication by CIRI in the journal Nature communications on November 25, 2019. Article
RsaC sRNA modulates the oxidative stress response of Staphylococcus aureus during manganese starvation Wed, 30/10/2019 Publication Publication by CIRI on Nucleic Acids Research on October 10, 2019. Article
Diverse conjugative elements silence natural transformation in Legionella species Fri, 18/10/2019 Publication Publication by the International Research Centre for Infectious Diseases (CIRI). Article
Pyrin dephosphorylation is sufficient to trigger inflammasome activation in Familial Mediterranean Fever patients Mon, 07/10/2019 Publication Publication by CIRI in the journal EMBO Molecular Medicine on October 7, 2019. Article
Inhibitory checkpoint receptors control CD8+ resident memory T cells to prevent skin allergy Mon, 27/05/2019 Press release, Publication Publication by the International Center for Infectiology Research (CIRI) in The Journal of Allergy and Clinical Immunology on January 14, 2019. Article
Regulation of measles virus gene expression by P protein coiled-coil properties Mon, 13/05/2019 Publication Publication by CIRI in Science Advances on May 8, 2019. Article
Enveloped viruses distinct from HBV induce dissemination of hepatitis D virus in vivo Wed, 08/05/2019 Publication Publication by the International Center for Infectiology Research (CIRI) in Nature Communications on May 8, 2019. Article
Necrotizing Soft Tissue Infections S.aureus - but not S.pyogenes- isolates display high rate of internalization and cytotoxicity toward human myoblasts. Wed, 24/04/2019 Publication Publication by the International Center for Infectiology Research (CIRI) in The Journal of Infectious Diseases on April 19, 2019. Article
Encouraging a holistic approach in the fight against infectious diseases Wed, 20/03/2019 News Infectious diseases, the main causes of human mortality according to the WHO, have always been a particular concern for society. Article
Genome editing in primary cells and in vivo using viral-derived Nanoblades loaded with Cas9-sgRNA ribonucleoproteins Thu, 03/01/2019 Publication Publication by International Center for Research Infectiology (CIRI) in Nature communications on January 3, 2019. Article
A serum protein factor mediates maturation and apoB-association of HCV particles in the extracellular milieu Thu, 13/12/2018 Publication Publication of the International Center for Infectiology Research (CIRI) in the journal Science direct on December 13, 2018. Article
Farnesoid X receptor-α is a proviral host factor for hepatitis B virus that is inhibited by ligands in vitro and in vivo Mon, 05/11/2018 Publication Article
Deciphering the link between skin allergies and the gut microbiota Mon, 24/09/2018 Publication Over the last few years, scientists have discovered connections between gut microbiota imbalances and various diseases. Now, in a study using mice, biologists from the CNRS, INSERM, and Claude Bernard Lyon 1 University —together with colleagues from the Institut Pasteur de Lille and the NIH (USA)— have revealed a surprising relationship between a viral detection system, the composition of the gut microbiota, and the development of skin allergies. Their findings, published in PNAS (September 24, 2018) suggest potential new therapies. Article