An effective duo against cancer

An effective duo against cancer

Thu, 20/06/2019


Publication of Laboratoire de chimie in Chemistry: A European Journal on June 5, 2019.

A “Multi‐Heavy‐Atom” Approach toward Biphotonic Photosensitizers with Improved Singlet Oxygen Generation Properties.

Abstract: Towards improved lanthanide complexes for two‐photon mediated singlet oxygen production: The very large inter‐system crossing efficiency results from the combination and interplay of bromine atom substituents, placed along the π‐conjugated antenna, and a heavy rare‐earth element coordinated to a central TACN ligand. Two‐photon activated singlet oxygen generation leads to tumor cell death, which illustrates the potential of this new class of compounds as theragnostic agents.

Source: A “Multi-Heavy-Atom” Approach Towards Biphotonic Photosensitizers With Improved Singlet Oxygen Generation Properties. Margaux Galland, Tangui Le Bahers, Akos Banyasz, Noëlle Lascoux, Alain Duperray, Alexei Grichine, Raphaël Tripier, Yannick Guyot, Marie Maynadier, Christophe Nguyen, Magali Gary-Bobo, Chantal Andraud, Cyrille Monnereau et Olivier Maury. Chemistry: A European Journal, juin 2019. DOI: 10.1002/chem.201901890

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